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Conversely, tretinoin, with its robust keratolytic and depigmenting actions, is more appropriate for moderate to severe cases where skin discolouration and hyperkeratosis are the primary issues

Funding This work was supported by the European Community under Innovative Medicines Initiative (IMI) Program (Grant No

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The standard schedule keeps each injection at 2.8 mg: daily in weeks 14, five times per week in weeks 58, and two or three times weekly in weeks 912

A randomized, double-blind and placebo-controlled 10-week clinical trial (see Fig