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Out of the three amino acids needed to make glutathione, cysteine is often the hardest for the body to source

In contrast, a secondary analysis of the Nutritional Prevention of Cancer showed, for the first time, an increased risk of type 2 diabetes mellitus in healthy subjects who received 200 g/d of Se for an extended period (Reference Stranges, Marshall and Natarajan9)

This is primarily due to the upregulation of phagocyte NADPH oxidase activity, which is a potent producer of superoxide ions (Vermot et al., 2021)

This accumulation of reactive oxygen species (ROS) disrupts meiotic spindle assembly, impairs spindle assembly checkpoint signaling, compromises chromatin cohesion, and ultimately deteriorates oocyte quality and developmental potential in women of advanced reproductive age (17)