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In gastrointestinal cancers, DOX induces autophagy via ROS generation, alongside Beclin1 upregulation, Bcl2 downregulation, AMPK and JNK activation, and Akt inhibition, whereas antioxidant pretreatment mitigates these effects

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Birth Defects Research Part A: Clinical and Molecular Teratology, 94(1), 22-30

Also, as disease severity increases, mental and motor dysfunctions deteriorate in unison, i.e., the less functional a patient is the more pronounced their central AND peripheral disturbances

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