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Seizure-promoting effect of blood-brain barrier disruption

In a bleomycin-induced rat model of pulmonary fibrosis, intravenous infusion of bone marrow MSCs (BMSCs) markedly reduced collagen deposition and hydroxyproline content in lung tissue via activation of the Nrf2/ARE signaling pathway, while increasing SOD activity and decreasing MDA levels, thereby effectively attenuating oxidative stress and tissue fibrosis [90]