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Biliary excretion of the glucuronide is mediated by the ATP-dependent multidrug resistance protein-2 (MRP-2) [3,4] and is the rate-limiting factor in the transport of bilirubin from plasma to bile

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Heres what tends to happen: Antioxidant protection weakens cellular stress builds up again Melanin production resumes skin tone slowly darkens Immune support dips slightly, especially if other antioxidants aren't present Skin clarity or brightness fadesthough not always dramatically What Ive found interesting is how the timeline varies