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Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery

doi: 10.1016/j.apsb.2021.12.007 346 YuYJiangLWangHShenZChengQZhangPet al

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Magnetic resonance spectroscopy (MRS) studies show that older individuals have lower GSH levels in the posterior cingulate and occipital cortices (Emir et al., 2011

Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours