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doi: 10.3390/foods12040791 Summary Keywords crocodilian oil, anti-inflammatory, skin health, energy metabolism, antimicrobial activity, scar reduction Citation Huang Y, Zheng X, Ming X, Jiao Q, Xiao W, Wu Q, Zheng L, Zeng Y, Cheng S, Wang R, Yang J, Bian Y and Yao J (2025) Recent advances in crocodilian oil research: bioactive components and potential therapeutic applications

[PMC free article: PMC2823947] [PubMed: 19878739] 73

In a study focusing on primary microglia cells treated with LPS, the anti-inflammatory PQQ pretreatment significantly reduced the production of NO, PGE2, and inflammatory cytokines (iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1, and MIP-1a) (Brodzikowska et al., 2022)

516,517 A recent 3-arm pilot randomized controlled trial indicated that ACT could significantly reduce the fear of cancer recurrence rate at each time point compared with baseline

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Fast forward to 2016, and now there are a total of 14 FDA-approved indications in the United States