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The models were conditioned on the matching variables and adjusted for education, country of birth and the Charlson comorbidity index

Putative mechanisms of action include: Decreased production of pro-inflammatory cytokines: curcumin can block the production of IL-12 by CD4, CD8, and NK cells, thereby reducing inflammation [77]

KG is derived from multiple metabolic pathways (Fig

The slower formation rate of 7 from Ser, relative to that of 1 from Cys, correlates with the higher pKa value of the serinyl hydroxyl group (predicted at 13.4 (ACD/I-Lab, 5.0.0.184, Advanced Chemistry Development, Inc., Toronto, ON, Canada, www.acdlabs.com, (2019)) compared to the cysteinyl thiol group (~8.4 (AAs and acidity values, (accessed 1 May 2019)), suggesting hydroxyl/thiol deprotonation might be (partially) rate limiting 39