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Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation

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PMID: 23692737

Expert Rev Clin Pharmacol 12(10):981989 Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

OTUD5 efficiently cleaves K48 linkages but not K29 linkages The data presented thus far indicate that OTUD5 is cooperatively modified by K29-specific TRIP12 and K48-specific UBR5, resulting in the conjugation of K29/K48-linked branched ubiquitin chains, and the biological importance of TRIP12OTUD5 antagonism is observed in TNF-induced NF-B signaling

Klein is a board certified Reproductive Endocrinologist, an Assistant Clinical Professor at the Icahn School of Medicine at Mount Sinai, and the Co-Founder of Extend Fertility