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In ADCC, the Fab domain of a mAb binds to a tumor antigen, and Fc domain binds to Fc receptors present on effector cells (phagocytes and NK cells), thus forming a bridge between an effector and a target cells

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Biomarker validation requires large-scale studies in diverse populations that are expensive and time-consuming to conduct

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Results In 317 individuals aged 3 months to 86 years, mitochondrial function was analyzed separately in isolated PBMCs and isolated platelets

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