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Different mouse models of neurodegeneration, such as the CK-p25, Tau P301S have demonstrated elevated C1q levels 19,49 , and previous data have shown that GENUS reduced C1q signal in both CK-p25 and P301S mice by GENUS 19

[PubMed: 12543978] 225

The mechanism involves activation of the EGFR/ERK/AP1 signaling pathway, leading to the upregulation of p21Cip1/WAF1 in a p53-independent manner

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To provide a systematic evaluation of the diverse therapeutic mechanisms mediated by COF-based nanoplatforms, Table 1 summarizes the morphologies, particle sizes, and underlying action mechanisms of representative COF systems

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress