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The human brain is especially vulnerable to oxidative stress because it accounts for only 2% of body mass but consumes 20% of oxygen 14

Also, whilst not explored here it is possible that sepiapterin treatment increased the infiltration of immune cells into the ischaemic retina

thus, some researchers have suggested using cimetidine as a complementary treatment for AALI (Woodhead et al., 2012)

Peptides sold outside regulated medication channels may not match the stated contents

Inclusion criteria Systematic reviews, meta-analyses, randomized controlled trials (RCTs), longitudinal observational studies No clinical signs or symptoms of dementia at onset of study Study must report onset of dementia, Alzheimer disease (AD), or cognitive decline as an outcome measure N 100 Observational period 2 years or longer Exclusion criteria Cross-sectional studies, case series, case reports Non-English studies Institutionalized subjects (inpatients) Outcomes of interest Onset of dementia or Alzheimer disease Change in cognitive function Question 2

Using the medication alone without these lifestyle adjustments may limit its effectiveness and reduce long-term success