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The underlying pathologic mechanisms of primary MS fatigue are poorly understood, with proposed theories including structural damage of white and gray matter, inflammatory processes including elevated cytokines, endocrine dysfunction, and maladaptive network recruitment attributable to distributed lesions or inflammation

Their long adolescence (3.5 years) hampers breeding, and their longevity (approximately 30 years in captivity) is clearly not supporting studies of senescence

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The heat-shock element is a functional component of the Arabidopsis APX1 gene promoter

Consequently, -CTX possesses substantial clinical value for the diagnosis, prognosis, and monitoring of OA

Exercise and lifestyle modification exert substantial antidepressant effects, especially for mild MDD (Marx et al., 2023)