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Some of the most current and emerging treatments for HE are discussed in the following section and depicted in Table 2

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Knockout of FKBP5 leads to upregulated phosphorylation of GR at the Ser240 and Ser243 sites (362), resulting in decreased levels of pro-inflammatory cytokines such as TNF-, IL-1, IL-6, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) (363)