It is possible that the increased binding with mutant FUS/TLS interferes with the normal dynamics of SMN complex assembly and/or trafficking/cycling, therefore leading to dysregulation of SMN function
Safety and tolerability of increasing doses of cb-839, a first-in-Class, orally administered small molecule inhibitor of glutaminase, in solid tumors
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parasites, has been shown to increase mucin gene expression in the intestines and also increase the humoral immune response to the parasite (Mockett and Rose, 1986
