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In brain tissue, misfolded proteins such as amyloid-beta and tau can sequester copper ions, creating local copper deficiency while simultaneously generating reactive oxygen species through aberrant metal-protein interactions

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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doi: 10.1371/journal.pone.0112945 108 Obara-MichlewskaM