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Specifically, this lncRNA is increased in I/R injury and is responsible for phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) downregulation, thus resulting in apoptosis (103)

The AMPK/mTOR/p70S6K signaling pathway induces autophagy to inhibit OC differentiation, thus regulating bone mineral density and improving bone mass [110]

28.4% of patients had potentially disease-causing variants of ABCB4, ABCB11, and ATP8B1genes with different liver disease phenotypes

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doi: 10.1016/j.neulet.2017.06.052 47