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Description

In turn, GATOR1 acts downstream of a protein complex named GATOR2, that is composed of MIOS (meiosis regulator for oocyte development), WDR24 (WD repeat domain 24), WDR59 (WD repeat domain59), SEH1L (Seh1-like nucleoporin), and SEC13 (Sec13 homolog nuclear pore and COPII coat complex component) and is required for mTORC1 activity

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17,117,119 Non-covalent interactions can occur over longer distances, e.g ., electrostatic and hydrophobic interactions can span tens of nanometers

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2-DG can cross the bloodbrain barrier and be transported into cells mainly through the glucose transport proteins GLUT1 and GLUT4

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C.et al (2004)

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However, only a few clinical studies have reported on this treatment strategy for RA

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P.VitekL.SchwertnerH

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