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MOTS-c has been demonstrated to disrupt the folate-methionine cycle and impede de novo purine biosynthesis, and it also regulates the expression of genes such as GLUT4, STAT3, and IL-10

These findings suggest potential red blood cell morphology alterations in FM patients, which may indicate underlying metabolic or inflammatory changes

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Piwowarczyk et al

Considering the dynamic changes of other signaling pathways during regeneration of the zebrafish lateral line system and the chick utricle, it will be critical to understand how other signals may act in concert with Wnt signaling to regulate the process of regeneration