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Scoparone prevents IL-1-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-B pathway

Menegus, F., Cattaruzza, L., Mattana, M., Beffagna, N

The current standard for drug-sensitive TB (DS-TB) is a 6-month regimen comprising isoniazid (INH), rifampin (also known as rifampicin) (RIF), pyrazinamide (PZA), and ethambutol (EMB), starting with a 2-month intensive phase of all four drugs, followed by 4 months of INH and RIF (Drug-Resistant Tuberculosis, 2024)

Notably, SLC38A9 is necessary for not only leucine but also other essential amino acids (e.g., glutamine, tyrosine, and phenylalanine) that are generated via lysosomal proteolysis and efflux from lysosomes in an arginine-stimulated fashion to activate mTORC1 (Rebsamen et al., 2015

Brit Med Bull 49: 481493