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The lactams 33 and 34 comprising 14-membered ring systems were most active in the series but nonetheless 100-fold less potent than the best disulfide and carba analogues (Barlow et al., 2020)

Long-term use of cyanocobalamin can build up cyanide in the body

Since this mechanism works to tune the ratio between excitatory and inhibitory synaptic inputs, it is especially important over developmental periods when circuits are maturing

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