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None of these pathways directly substitute for another, which is part of why researchers interested in a fuller picture of metabolic regulation may look at all three within the same body of literature not to combine effects, but to understand how separate systems might interact at a mechanistic level

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Research published in Biomedicine & Pharmacotherapy investigated the effects of digestive enzyme supplementation on gut health in individuals with functional dyspepsia

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For example, depletion of ZO-1 destabilizes the barrier to large solutes, but does not disrupt the claudin-based pores 38

Flare-ups commonly coincide with menstruation, pregnancy, or changes in birth control