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Additionally, HGF binding to c-Met and subsequent phosphorylation of intracellular transducers such as: PI3K (p85 subunit), Gap, Ras, PLC-gamma, Src related tyrosine kinase, Grb-2, Gab-1, IRS-1, IRS-2 (Figure 1) (56, 66) has been shown to promote HGF functions in the cell

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