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Refractory RA is when an individual with RA fails to respond to DMARDs treatment (196)

Rents have outpaced income growth in recent years and more people were homeless in 2023 than ever before

The deposition of a considerable amount of antibodies, along with complement activation and immune cell activation, might result in acute liver failure due to antibody-mediated inflammation [90]

Therefore, some scholars have proposed the concept of "glutamine hijacking," which suggests that targeted inhibition of glutamine metabolism in tumor cells can alleviate glutamine competition in the tumor microenvironment, release glutamine for immune cell utilization, and promote anti-tumor immune response [134]