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Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

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Front Pharmacol 13:914467 Araf Y, Moin AT, Timofeev VI, Faruqui NA, Saiara SA, Ahmed N, Parvez MSA, Rahaman TI, Sarkar B et al (2022) Immunoinformatic design of a multivalent peptide vaccine against mucormycosis: targeting FTR1 protein of major causative fungi