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Conclusion MDSCs are pivotal mediators of immune evasion in cancer, playing a dual role in both immunosuppressive and non-immunosuppressive tumor-promoting activities, such as supporting cancer stem cell survival, inducing angiogenesis, driving the epithelialmesenchymal transition, and contributing to the formation of pre-metastatic niches

At baseline, trained nurse interviewers administered a structured questionnaire to each subject to collect comprehensive information on demographics, occupation, lifestyle habits, medical history, usage of medication and dietary supplements, alcohol consumption, and past cigarette smoking history

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