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Gemcitabine induces CAFs to secrete exosomes containing miR-3173-5p, which inhibits the expression of ACSL4, thereby decreasing PUFA binding to phospholipids and enhancing resistance to ferroptosis in PDAC cells [41, 42]

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Probably, if all cysteine residues were in the reduced form (with free sulfhydryl groups) high percentage of helical fragments would be possible

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