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The safety evaluation that carries out according to peeling/decortication: on baseline, 27 experimenters (77.1%) have peeling or decortication to a certain degree, and 8 experimenters (22.9%) do not have this symptom.In the 6th week, in 16 experimenters (47.1%), there are not visible peeling or decortication, in 7 experimenters (50%), there are slight peeling or decortication, and only have moderate peeling or decortication 1 experimenter (2.9%).Observed maximum peeling or decortication scoring improve in 7 experimenters with respect to baseline in research process, in 20 experimenters, do not change, and in 8 experimenters, worsen.Whole peeling/decortication scoring improves in 16 experimenters with respect to baseline, in 14 experimenters, does not change, and in 5 experimenters, worsens

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