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Evidence (sorafenib): A phase III, randomized, double-blind, placebo-controlled study (DECISION [NCT00984282]) evaluated sorafenib in patients with progressive, iodine-refractory, differentiated thyroid cancer.[21] This trial included 417 patients with locally advanced or metastatic RAI-refractory thyroid cancer (papillary, follicular [including Hrthle cell], and poorly differentiated tumors) whose disease had progressed within the past 14 months

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Because SO 2 and O 2 levels are related to large differences in MOx reaction rates, those levels are candidate indicators of the rate of MOx oxidation

DLD in gel activity assay (diaphorase) 30 g of mitochondrial matrix lysates, 0.25 g of rhDLD or 30 g of whole cell HEK293T lysates were run on Blue Native PAGE at 150 V for 1 h, followed by 1 h at 250 V on ice

64 Macrophages with a pro-inflammatory phenotype are categorized as M1 macrophages, while those with anti-inflammatory or immunosuppressive phenotypes are classified as M2 macrophages