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Acknowledgements We thank the researchers house Figdraw for illustration support for this article and the Central Laboratory of Organ Transplantation/Stem Cell Laboratory/Inner Mongolia Autonomous Region Engineering Laboratory for Genetic Test and Research of Tumour Cells of the Affiliated Hospital of Inner Mongolia Medical University for support of this article

Postnatally, in vitro studies have also demonstrated that the IGF-I regulates the expression rate of genes encoding steroidogenic enzymes that involved in the biotransformation of steroid hormones in the testis[131133]

Int Abstr Surg 71(3):209240 Williams JC Jr., Al-Awadi H, Muthenini M, Bledsoe SB, El-Achkar T, Evan AP et al (2022) Stone morphology distinguishes two pathways of idiopathic calcium oxalate stone pathogenesis

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However, there are significant precautions and concerns regarding its use, particularly related to tumor growth and the lack of rigorous human studies

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