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In another study, luteolin (1 mg/kg) was assessed in vivo in OVA-sensitized BALB/c mice [158]

They also showed in this paper that feeding the low-protein diet during the dosing period led to serious cases of liver toxicity: Some degree of bile duct proliferation was observed in all animals dosed with AFB1

Congruently, expression of glutamine synthase (GS), an effector molecule of the -catenin pathway which is expressed by peri-central hepatocytes, increased significantly by IF in pIVCL mice livers compared to sham (fold change 1.85, p value 30%, and veterans for whom LSM was obtained after HCC diagnosis were excluded