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In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

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Moringa rivae leaf extracts attenuate Complete Freunds adjuvant-induced arthritis in Wistar rats via modulation of inflammatory and oxidative stress biomarkers

doi:10.17849/insm-45-02-075-080.1 Kabat, Geoffrey C et al

Studies have shown that in a mouse model of ischemic stroke, the level of GSH in neurons is significantly decreased, the degree of lipid peroxidation is enhanced, and the activity of GPX is decreased 71