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Available at: Accessed 12 Dec 2023 University of Alabama at Birmingham Traumatic Brain Injury Model System (2021) In-home cognitive stimulation guidebook: Activities to stimulate thinking skills of people with brain disorders

This pathway can be interrupted by the introduction of VPA, which leads to a reduction of free coenzyme A, acetyl-CoA, and carnitine, and results in the decreased availability of cofactors necessary for the function of urea cycle and an increase in NH3 production.[15,16] Because VPA-induced metabolic disorders including hyperammonemia could be mediated at least in part by carnitine deficiency, it has been hypothesized that levocarnitine supplementation may prevent, correct, or attenuate these adverse effects[15,17] Several studies or isolated clinical cases have suggested the potential value of oral levocarnitine in reversing carnitine deficiency or preventing adverse effects due to VPA-induced dysfunction of beta-oxidation

Moreover, a study investigated the potential benefits of EGCG against memory impairment, amyloidogenesis, and neuroinflammation caused by systemic inflammation