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doi: 10.1016/j.autrev.2024.103648 86 FrankMMHamburgerMILawleyTJKimberlyRPPlotzPH

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Inhibition of COX-2 Expression COX-2 is an inducible enzyme predominantly upregulated in response to inflammatory stimuli and is critical for the biosynthesis of pro-inflammatory prostaglandins, notably prostaglandin E 2 (PGE 2 )

By expanding the intracranial artery, puerarin protects the brain from cerebral ischaemia and increases blood flow to the brain

Therefore, overlap with another form of anticoagulation with a faster onset, historically unfractionated or low molecular weight heparin, is required for the first 5 days and until the INR produced by warfarin therapy is in the therapeutic range for 2 consecutive days