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Many preclinical studies conclusively shown that berberine plays a therapeutic role in many central nervous system disorders such as Alzheimer s disease, cerebral ischemia, depression, schizophrenia, epilepsy, and anxiety (Fan et al., 2017

Another possible explanation for the discrepancy between the studies is the method used to assess insulin resistance

doi: 10.3390/antiox12030602 69

While there is currently a registered study to examine the effect of sulforaphane in patient populations with attention-deficit disorder with or without hyperactivity in children 612 years old (NCT06594536), as well as a study currently recruiting to evaluate the effects of sulforaphane in PD patients (NCT05084365), and a clinical study registered to examine AD (NCT04213391), there remains large gaps in the literature regarding the efficacy of sulforaphane as a treatment for neurological disorders

The resulting clean reads were assembled into unigenes using Trinity software (v2.13.2) after Q20, Q30, GC-content and sequence duplication level of the clean reads were calculated

myo-inositol oxygenase offers a possible entry point into plant ascorbate biosynthesis. Plant Physiol 134 (3), 12001205