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mTORC1 is activated on lysosomes in response to GF signalling, despite the fact that only a small fraction of the key mediator of GF signalling, RHEB, is transiently localized on lysosomes 43,44

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Recent studies have identified artesunate, traditionally an antimalarial drug, as a potential therapeutic agent for BL due to its ability to trigger ferroptosis, a specialized form of cell death

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Subsequently, nuclear translocation of the AIF/MIF complex causes chromatin condensation and DNA fragmentation, ultimately leading to cell death (108110) ( Figure 7 )

They are characterized by multi-pathway and multi-target effects, low adverse reactions, and suitability for long-term consumption (18), demonstrating superior functionality and safety compared to traditional single-chemistry medicines or ordinary food