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One hypothesis now is that ME/CFS is caused, or partly caused, by impaired TRPM3 ion channels.[ref] Naltrexone acts on the mu-opioid receptors, which then can affect other cellular processes

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Augmented immunological responses were noted, characterized by heightened infiltration of CD 4 and CD 8 T cells, alongside the elevation of pro-inflammatory cytokines (IL-2, IFN-), hence substantiating the immunoadjuvant function of GLPs

J Med Econ 14(5):584593

Nucleic Acids Res 36: 1-6