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Perkovic V, de Zeeuw D, Mahaffey KW et al (2018) Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials

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Aspartame-exposed male and female mice had elevated fasting blood glucose levels and aspartame-exposed males presented decreases in insulin sensitivity

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93 Glutamatergic hyperactivity with its ensuing excitotoxicity and oxidative stress are also thought to play a role, making NAC a potential treatment option

performed in a cohort of patients with chronic HF exacerbation and HFpEF.15 In this respect, previous studies have also reported equal prognostic significance of either admission levels or discharge levels of NPs in patients with HFpEF hospitalised for acute decompensated HF.16 NPs also confer the same relative risk information in HFpEF as in HFrEF in this acute setting, with similar adjusted prognostic relative risks in patients with both phenotypes for the relative changes in NT-proBNP levels during hospitalisation ( Figure 2 ).17 Finally, in the field of patient management, it has been suggested that measuring NP concentrations should be useful in guiding therapy in the whole spectrum of HF, including the group of patients with HFpEF.18,19 However, current evidence does not support the routine measurement of BNP or NT-proBNP to guide titration of therapy