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Although constitutive expression of COX-2 in hepatocytes and enhanced production of COX-2-derived PGE2 in white adipose tissue protect against diet-induced insulin resistance and maintain intermittent fasting-elicited insulin sensitivity benefits by promoting systemic energy expenditure and reducing inflammatory response, 107,112 epidydimal adipose tissue COX-2 is potently and positively related to impaired glucose and insulin tolerance in obese rats

10.1016/j.cmet.2017.10.007 Cell Metab

C., Dugailly, P.-M., & Sobczak, S

Examples of drugs requiring CYP2D6 to become active and produce the intended effects are tramadol , codeine , and tamoxifen

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