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Females exhibit a greater sensitivity to opioids, possibly due to the effects of female hormones on the density of opioid receptors or changes in GABA receptors, leading to a higher incidence of ADRs (Ueno 2009

Furthermore, the functional assessments of lower limbs of mice, including the reflexive mechanical pain-related responses experiment 34 and thermal pain-related responses experiment 35 , were conducted using the von Frey test and hot plate test, respectively

(7) Intensified athletic performance - Caffeine intensifies athletic performance by increasing endurance, reducing perceived exertion, and enhancing focus and energy levels during physical activities

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Neither requires intramuscular delivery

This method is often utilized for individuals who have difficulty absorbing the vitamin through food sources or oral supplements, such as those suffering from pernicious anemia or certain gastrointestinal disorders