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Although dryness (sicca) of the eyes and mouth are the classically described features, dryness of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia, are common ( Digestive involvement is frequent in pSS, including autoimmune disorders, such as chronic atrophic gastritis, esophageal motility dysfunction, lymphocytic colitis, primary biliary cholangitis and autoimmune hepatitis ( pSS-related atrophic gastritis and associated PA may require parenteral or sublingual vitamin B12 supplementation (2)

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Maintenance Treatment While there is no body of evidence available to answer the question of how long a patient treated with ziprasidone should remain on it, a maintenance study in patients who had been symptomatically stable and then randomized to continue ziprasidone or switch to placebo demonstrated a delay in time to relapse for patients receiving ziprasidone capsules [see Clinical Studies (14.1)]

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Srinivasan, A., Wong, F

Cancers 14 , 1516 (2022)