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Central to this approach are dose modification protocols guided by the Common Terminology Criteria for Adverse Events (CTCAE), which provide standardized thresholds for adjusting or withholding treatment based on toxicity grade

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doi: 10.1186/s13020-024-00912-2 21

Folate-mediated One-carbon Metabolism (FOCM) is defined as a metabolic network characterized by extensive compartmentalization, with reactions distributed across the cytoplasm, nucleus, and mitochondria [3]

These results suggest a fusion between the late endosome (Rab7) and lysosome (Arl8b) in the neurites of hippocampal neurons and deficient endocytic degradation

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