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A reduced GSH/GSSG ratio was observed in the liver of hyperlipidemic rats (39% vs

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Oxid Med Cell Longev 3:428433 Moosavi SM, Ashtiyani SC, Hosseinkhani S, Shirazi M (2010) Comparison of the effects of l-carnitine and -tocopherol on acute ureteral obstruction-induced renal oxidative imbalance and altered energy metabolism in rats

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However, with the depletion of GSH in liver cells, reactive metabolites gradually accumulate, resulting in cytotoxicity, which eventually leads to liver cell necrosis and acute liver failure (Figure 3)