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But a key factor is often missing from that line of reasoning: such knowledge typically becomes productive only when private sector R&D turns it into commercial goods consumers want

No statistically significant pCR differences were noticed between the groups, however, the subgroup analysis showed that for HR+ patients under 40 years old, combination therapy with paclitaxel + olaparib can lead to higher pCR rates

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The Harmonic plus Noise model captures this by combining the output of an additive synthesizer with a stream of filtered noise (Serra & Smith, 1990