alpha glutathione s transferase phase ii biomarker S-transferase Characterization of Cytosolic Glutathione S-Transferases

a reduction product, free APAP

Krakow in numbers 2017

Some references use: Normal value as 200 to 900 pg/mL OR Other sources = 206 to 678 ng/L

Kuda, O

This product is not recommended for children or growing adolescents, or pregnant or lactating women

Principles of treatment The aim of treatment is to achieve a T4 level in the normal range a TSH level in the normal range AND The doses is primarily titrated to the TSH level The typical dose is 1.6g/Kg, but the dose should be started low and titrated up to this Typically this means doses are in the 100-200g per day range Initially give 25-50g, and review after 6 weeks Start at the lower end for frail and elderly patients Adjust the dose every 6 weeks so that TSH levels are in the normal range (not suppressed) Low TSH suggests over-replacement of T4 (even if T4 is not elevated) titrate the dose down until TSH returns to the normal range High TSH suggests under-replacement increase the dose of levothyroxine The half life of T4 is about 7 days, so any change in the dose will not be clinically noticeable for about 4 weeks