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This difficulty limits using H 2 S gas as a drug in basic research and clinical trials

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Amino Acids (this issue) Diwakar L, Ravindranath V (2007) Inhibition of cystathionine--lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS

But unlike reactants which are consumed by the reaction and products that are made by the reaction, cofactors remain unchanged and so they can catalyze the reaction repeatedly

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