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Wh-ereas the three studies finding a significant therapeutic efficacy of the COX-2 inhibitor were based on patients with a short illness period,113114115 the one study with a negative result was conducted with patients with relatively chronic schizophrenia.116 A meta-analysis showed that augmentation of anti-inflammatory drugs to the antipsychotics would be a potential therapeutic options in patients with schizophrenia, although more evidences should be accumulated.117 Several antioxidant treatment approaches have reported that antioxidants are effective for improving psychopathology in schizophrenia

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