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This was demonstrated by the fact that administration of the peptide counteracted 5-HT receptor-dependent symptoms induced by pargyline + L-tryptophan, i.e., hyperthermia and wet dog shake related to 5-HT2A agonism, but not 5-HT1A-related forepaw treading, hind limb abduction, or hypothermia

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Heinzerling L, Ascierto PA, and Dummer R, et al (2019) Adverse events 2.0-Let us get SERIOs: new reporting for adverse event outcomes needed in the era of immunooncology Eur J Cancer 112 2931 PMID: 30903870 77

Since infliximab cannot penetrate the blood-brain barrier, this finding indicates that effective treatment of neuroinflammation could be achieved by modulating peripheral immune mechanisms

Appl Sci 13(4)