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Firstly, we discussed the epidemiology and various risk factors such as genetic mutations ( BRCA1/2, TP53, PTEN ), hormonal influences, several lifestyle risk factors (obesity, smoking, etc.), and environmental factors (chemical exposure, air pollutants, etc.)

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GA also stimulates the expressions of TJ proteins, ameliorates cell apoptosis, and oxidative stress, and suppresses the activation of the NF-B/MAPK pathway to alleviate LPS-induced intestinal inflammation in Caco-2 cells [345]

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Reference Sylvestre-Gonon, Law, Schwartz, Robe, Keech, Didierjean, Dubos, Rouhier and Hecker2019)

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