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Vargas Buonfiglio LG, Cano M, Pezzulo AA, Vanegas Calderon OG, Zabner J, Gerke AK, et al

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These peptides mimic the spatial conformation of the parent (native) molecules while exhibiting significantly enhanced resistance to enzymatic degradation, thereby enabling prolonged biological activity and reduced immunogenicity

The addition of PI3K inhibitors, including, MK2206, LY294002, IC87114, idelalisib, and TGR-1202, during expansion has been shown to maintain CAR T cells in a less differentiated state leading to increased downstream anti-tumor efficacy and persistence of CAR T cells in vivo (105, 121, 158)

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